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                                      Clinically Relevant Sleep Issues in Parkinsons’ Disease

                                      by Andrew Smith
                                      February 6, 2023
                                      in Health
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                                      Clinically Relevant Sleep Issues in Parkinsons' Disease
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                                      Sleep problems are common in people with Parkinson’s. The disease changes the way your body makes chemicals that help you sleep, and some medications can make it harder to fall asleep. People with Parkinson’s also often have mental health challenges, which may keep them from sleeping well or waking them up in the middle of the night. If you have these problems, your doctor can recommend treatments for them.

                                      Sleep-Wake Organization Disturbances

                                      Sleep-wake organization disturbances are common in neurodegenerative diseases, most notably PD, and have significant negative effects on patient quality of life (QoL) and caregiver burden. These disruptions can occur due to chemical changes in the brain that lead to drowsiness or wide awakeness, pill side effects, and mental health challenges such as depression or anxiety. Parkinson’s patients who really are sleepy find Modvigil 200 Buy Online to be helpful. modafinil can help manage symptoms.

                                      While a large body of research has examined the effects of different DBS techniques on sleep-wake disturbances, the mechanism by which different targets at different sites modulate sleep architecture is still unclear. Several studies have used subjective and objective measures to assess sleep outcomes post-DBS, ranging from PSG, and actigraphy, to Zurich questionnaires.

                                      In one study, Bauman-Vogel and colleagues assessed a group of 50 PD patients pre- and post-DBS with the PSQI, ESS, and actigraphy to determine sleep parameters. They found that after surgery, patients reported an increase in total sleep time and EDS reduction compared to pre-DBS. Other findings included an improvement in sleep efficiency and duration of slow wave and REM sleep.

                                      Nocturnal Hallucinations

                                      During sleep, patients with Parkinson’s disease may have nocturnal hallucinations (visions of people, animals, or other objects) that may be very vivid and frightening. They can also experience confusion and may feel like they’re being watched or followed.

                                      These are most likely to occur when patients have not slept well or do not get enough sleep. They may also be more severe in patients who are depressed or have dementia. A treatment of Artvigil 150 Australia is in to treat daytime sleepiness in people with Parkinson’s.

                                      In some cases, these nocturnal hallucinations and confusion may be due to a disorder is known as rapid eye movement sleep behavior disorder (RBD), which is characterized by thrashing, talking, or yelling while sleeping during the rapid eye movement (REM) stage of sleep. This is thought to be caused by impaired sleep paralysis and can occur in patients who are taking L-dopa or dopamine agonist medications during the night.

                                      Restless Legs Syndrome

                                      Restless legs syndrome (RLS) is a common condition that causes you to have an irresistible urge to move your legs because they are itching, tingling, or “creepy-crawly.”

                                      RLS can affect the quality of your sleep. It may interfere with your ability to get to sleep or stay asleep, and it can be a problem for your sleeping partner as well.

                                      Medications, such as dopamine agonists or levodopa, can help to relieve your symptoms. You may also need to make some changes in your daily lifestyle to help you better manage your RLS.

                                      Studies have found that people with PD are more likely to have restless legs syndrome than people without PD. These findings suggest that RLS may be a symptom of Parkinson’s disease and that PD is associated with an etiology of this disorder. However, more research is needed to understand the link between these two disorders. Researchers hope that combining efforts to study this condition will lead to better treatments for patients with both RLS and PD.

                                      Hypersomnolence

                                      Insomnia, or difficulty falling asleep and staying asleep, is one of the most common sleep issues seen in people with PD. Horvat says it’s often linked with depression, and that can impact both sleep quality and quantity.

                                      While most of us experience bouts of sleepiness here and there, for some people it’s a constant, unrelenting problem. The reason for this is still unknown, but it may be because their brains don’t work like they used to.

                                      Some of this can be attributed to medications such as carbidopa and levodopa (Sinemet). Other possible causes include pain, anxiety, or other health conditions, she adds.

                                      Narcolepsy, a disorder of hypersomnolence that affects up to 1 percent of the population, can also cause excessive sleepiness. In narcolepsy type 1, the cause of hypersomnolence is low levels of a chemical (neurotransmitter) called hypocretin in the brain. In narcolepsy type 2, however, the cause of hypersomnolence can be different.

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